Relationship of Cx-reactive protein response to induction of liver and kidney catalases following hematin administration into rabbits.

The relationship of rabbit Cx-reactive protein (CxRP) and the enzymatic activity of hepatic and kidney catalases in rabbits following i.v. hematin administration has been examined sequentially. The early increases in rab bit liver and kidney catalatic activities were accompanied by the corresponding decreases in ßCxRP and an early appearance of 7 CxRP after hematin administration. Immunoelectrophoretic analysis of serum samples revealed two types of CxRP: a preexisting, although variable in concentration, ßCxRP and a 7 CxRP which appeared within 3 hr and then disappeared after 24 hr following a single injection of hematin. Adjuvant-treated rabbits showed slight depression of liver catalase with an in crease in ßand 7 CxRP levels. When hematin was ad ministered to these animals, a rise in both liver and kidney catalases ensued with a concomitant decrease in serum ßand 7 CxRP's 3 hr after hematin. Actinomycin